Synthesis, Structure, and Hemorheological Activity of Pentasubstituted Cyclohexanol

Irina V. Palamarchuk, Zarina Shulgau, Shynggys D. Sergazy, A. M. Zhulikeeva, Yu. V. Gatilov, Ivan V. Kulakov

2021

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DOI 10.1134/s107036322112015x
Data confidence 70 medium
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Abstract

Abstract The intramolecular condensation of chalcone (benzylideneacetophenone) in a DMSO solution in the presence of KOH gave (4-hydroxy-2,4,6-triphenylcyclohexane-1,3-diyl)bis(phenylmethanone). Structure of the synthesized derivative was proved by 1H, 13C NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The obtained cyclohexanol derivative shows hemorheological activity: it is able to inhibit the growth of the viscosity of whole blood during the formation of the syndrome of increased blood viscosity in vitro.