Hengshanols F and G, two new acylphloroglucinols from Hypericum hengshanense

Siyi Liao, Qindi Han, Wenqing Huang, Cong Jing, Xiuteng Zhou, Alibek Ydyrys, Qinxiong Lin, Xinzhou Yang

2026

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DOI 10.25135/rnp.2602.3748
Data confidence 70 medium
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Abstract

Two new acylphloroglucinols, hengshanols F and G (1 and 2), were isolated from Hypericum hengshanense, together with nine known phloroglucinol derivatives: dauphinol F (3), 4-geranyl-2-(2′-methylpropionyl)-phloroglucinol (4), 1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylpropan-1-one (5), 1-[5,7-dihydroxy-2-methyl-2-(4-methylpent-3-enyl)-chroman-8-yl]-2-methylbutan-1-one (6), empetriferdinan B (7), tomoeone B (8), uraloidin A (9), hyperbeanol P (10), ascyronone G (11). The structures of the two new acylphloroglucinols were determined by 1D NMR (1H, 13C, DEPT), 2D NMR (HMBC, COSY, HSQC), HRMS and electronic circular dichroism (ECD). The structural elucidation revealed that all isolated compounds (1–11) are phloroglucinol derivatives. In cell viability assays, compounds 1, 5, 8, and 9 significantly reduced cell viability. whereas compound 6 promoted ATP production and enhanced mitochondrial activity.