Front Cover: Copper‐Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta‐2,3‐dienoate for the Synthesis of 1,6‐Dihydropyridines (Eur. J. Org. Chem. 10/2019)

Chao Liu, Gaigai Wang, Yuqing Wang, Olga P. Pereshivko, Vsevolod A. Peshkov

2019

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DOI 10.1002/ejoc.201900303
Data confidence 70 medium
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Abstract

The Front Cover shows a new method for the fast assembly of 1,6-dihydro­pyridine core through a copper(I) bromide-catalyzed reaction of A3-coupling-derived propargylamines with ethyl buta-2,3-dienoate. The overall transformation involves the addition of secondary propargylamines to ethyl buta-2,3-dienoate and subsequent cycloisomerization of resulting 1,5-enynes. The dancing couple serves as a metaphorical representation of the process under­lying the alliance of science and art. More information can be found in the Full Paper by O. P. Pereshivko, V. A. Peshkov et al.