Supramolecular inclusion complexes of β-cyclodextrin with 4-(acyloxy)-4-(cyclopropylethynyl)-1-(2-ethoxyethyl)piperidines

Т. М. Сейлханов, Iskakova Tynyshtyk Kadyrovna, Symbat Zhumakova, T. G. Bimurzayeva, Olzhas T. Seilkhanov, L. A. Nazarenko, Калдыбай Джайловович Пралиев

2017

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DOI 10.1134/s1070363217020190

Data confidence 70 medium

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Abstract

4-Acyloxy-4-(cyclopropylethynyl)-1-(2-ethoxyethyl)piperidines have been synthesized by reaction of 1-(2-ethoxyethyl)piperidin-4-one with cyclopropylacetylene and subsequent acylation of intermediate 4-(cyclopropylethynyl)piperidin-4-ol. The resulting esters react with β-cyclodextrin to give supramolecular inclusion complexes. The complexation is accompanied by inclusion of the N -ethoxyethyl fragment of one substrate molecule in the inner cavity of one receptor molecule. The structure of 4-acyloxy-4-(cyclopropylethynyl-1-(2-ethoxyethyl)piperidines and their inclusion complexes with cyclodextrin has been studied by NMR spectroscopy.