Synthesis of 2‐Alkynyl‐ and2‐Amino‐12 H ‐benzothiazolo[2,3‐ b ]quinazolin‐12‐ones and Their Inhibitory Potential against Monoamine Oxidase A and B

Behzad Jafari, Saquib Jalil, Sumera Zaib, Sayfidin Shahobidinovich Safarov, Muattar Khalikova, Djurabay Khalikov, Meirambek Ospanov, Nazym S. Yelibayeva, Shynar Zhumagaliyeva, Zharylkasyn A. Abilov

7 more authors

Mirgul Zh. Turmukhanova, Sergey Kalugin, Ghazwan Ali Salman, Peter Ehlers, Abdul Hameed, Jamshed Iqbal, Peter Langer

2019

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DOI 10.1002/slct.201903300

Data confidence 70 medium

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Abstract

Abstract 2‐Alkynyl‐ and 2‐aminobenzothiazolo[2,3‐ b ]quinazolin‐12‐ones have been synthesized by Palladium catalysed Buchwald‐Hartwig and Sonogashira reactions. Synthesized derivatives were further evaluated for their role as potential inhibitors of monoamine oxidase A and B (MAO−A and B) isozymes. Most compounds possess moderate to excellent inhibitory potential against MAO−A and MAO−B. The 2‐amino‐substituted derivatives show a significantly higher activity as compared to 2‐alkynyl‐ and previously reported 2‐aryl derivatives. Studied compounds might be employed as novel monoamine oxidase inhibitors and may provide insights for the development of new drug candidates against neurological diseases.