Synthesis, Chloramphenicol Uptake, and In Vitro Release of Poly(AMPS–TEA-Co-AAm) Gels with Affinity for Both Water and Alcohols

Tingting Weng, Jianwei Guo, Xinming Li, Yingde Cui, Buning Zhang, Sergey V. Mikhalovsky, Susan R. Sandeman, Carol A. Howel, Lyuba I. Mikhalovska, Irina N. Savina

2013

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DOI 10.1080/00914037.2013.769250
Data confidence 70 medium
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Abstract

Novel copolymeric gels of poly(AMPS–TEA-co-AAm) with superabsorbency in both water and alcohols were synthesized by neutralizing 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS) with triethylamine (TEA) followed by copolymerizing the resulted salt with acrylamide (AAm) in aqueous solutions using N,N′-methylenebisacrylamide (MBAm) as a crosslinker, and ammonium persulfate (APS) as an initiator. By swelling the xerogel of poly(AMPS–TEA-co-AAm) in the drug solution followed by removing the solvent to give drug-polymer conjugate, the incorporation of a model drug, chloramphenicol, into the gels was investigated by using water and alcohols as solvent, respectively. The in vitro drug release profile of the drug-polymer conjugate was investigated in PBS. The results showed that poly(AMPS–TEA-co-AAm) gels exhibited superabsorbency in both water and a series of alcohols; and the alcohol-facilitated uploading of chloramphenicol into the gels was much greater than that achieved in water. The poly(AMPS–TEA-co-AAm) gels exhibited a similar drug release profile with conventional hydrogels; and only part of the drug uptaken by the gels was released as a result of poor aqueous solubility of chloramphenicol.