ELM—the eukaryotic linear motif resource in 2020

Manjeet Kumar, Marc Gouw, Sushama Michael, Hugo Sámano‐Sánchez, Rita Pancsa, Juliana Glavina, Athina Diakogianni, Jesús Alvarado-Valverde, Dayana Bukirova, Jelena Čalyševa

4 more authors

Nicolás Palópoli, Norman E. Davey, Lucia Beatriz Chemes, Toby J. Gibson

Nucleic Acids Research, 2019

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1093/nar/gkz1030

Data confidence 85 high

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Abstract

The eukaryotic linear motif (ELM) resource is a repository of manually curated experimentally validated short linear motifs (SLiMs). Since the initial release almost 20 years ago, ELM has become an indispensable resource for the molecular biology community for investigating functional regions in many proteins. In this update, we have added 21 novel motif classes, made major revisions to 12 motif classes and added >400 new instances mostly focused on DNA damage, the cytoskeleton, SH2-binding phosphotyrosine motifs and motif mimicry by pathogenic bacterial effector proteins. The current release of the ELM database contains 289 motif classes and 3523 individual protein motif instances manually curated from 3467 scientific publications. ELM is available at: http://elm.eu.org.