Abstract
Global water pollution driven by industrial and agricultural expansion has resulted in the widespread occurrence of persistent contaminants, particularly pharmaceuticals and heavy metals, in groundwater systems. Conventional treatment methods often prove inefficient, costly, and environmentally unsustainable, highlighting the need for innovative in situ remediation technologies. Permeable Reactive Barriers (PRBs) have emerged as a promising and energy-efficient solution for the long-term purification of contaminated aquifers. Their efficiency arises from passive operation, relying on natural groundwater flow to promote pollutant removal through adsorption, ion exchange, precipitation, and redox-driven transformations. This review emphasizes the superior performance of materials such as Activated Carbon, Biochar, Zeolites, and Zero-Valent Iron (ZVI) in the immobilization and reduction in pharmaceuticals and metal ions. Key challenges to PRB longevity include permeability loss and reactive media depletion due to mineral precipitation and biofouling. Advances in hybrid PRB configurations, coupled with electrokinetic (EK) and bioreactor systems, and predictive modeling, particularly Artificial Neural Networks (ANNs), offer pathways to enhance performance, optimize design, and ensure sustainable operation. Overall, PRBs represent a scalable and environmentally sound approach to groundwater remediation, with future progress relying on the development of multifunctional, regenerable materials and integrated design strategies.