Abstract
This article is devoted to the determination of physicochemical properties, such as determination of appearance, solubility, concentration of hydrogen ions (pH), mass fraction of moisture (MFM) in vaccine preparations, one of the main physicochemical quality indicators that makes it possible to assess the quality of the finished product. Its shelf life, consumer properties and safety depend on the quality level of drugs. To assess the quality, a laboratory analysis was carried out, the results of which compared the actual values with the standardized ones. The quality control of the vaccine was carried out in accordance with the standards adopted in the biological industry for the production and control against Newcastle disease from the La Sota strain. The object of the study was a live vaccine of three series, intended for the prevention of ND in breeding and commercial poultry farms, manufactured at the Research Institute of Biological Safety Problems of the Ministry of Health of the Republic of Kazakhstan. As a result of the work carried out, all values were within the acceptable limits, which complies with the requirements of ST 405-1919-04 GP-100-2019