Abstract
This article contains some drugs which inhibit the nucleic acids in versatile groups e.g., anti-parasites (metronidazole, chlorproguanil, quinolines, oxamniquine (anti-bilharzial)). Anti-bacterial (quinolones, actinomycins, doxorubicin, nitrofurantoin), some of them act on protein synthesis inhibition via DNA e.g., aminoglycosides antibiotics, tetracyclines, chloramphenicol, lincosamides, macrolides, fusidic acid, ketolides, streptomycin, also RNA polymerase inhibitor and DNA coiling granules inhibitor, in addition to flucytosine as anti-fungal, coumarins used as nucleic acid inhibitor, later on indirect nucleic acid via inhibition some enzymes e.g., azaserine inhibit enzyme which responsible for nucleotide formation, 6-diazo-5-oxo-l-norleucine as anti-tumor, hadacidin, mycophenolic acid which inhibits DNA and RNA guanine formation, 6-mercapto purine, 5-fluro uracil which act as anti-cancer by inhibition of nucleoside phosphorylation, ethidium, actinomycin-D, echinomycin, daunorubicin, netropsin, bleomycin, anthramycin, neocarzinostatin, most of them anti-biotic anti-cancer drugs.