Abstract
Osteoma is one of the rare benign bone tumors and often presented asymptomatic through which could be expanded to close tissues. The current article will present a case report of giant frontal sinus osteoma and successful surgical treatment. The described tumor's size is astounding and among one of the biggest currently reported. In a discussion section, we try to provide the helpful groundwork for this disease’s etiology and describe the surgical approach performed. The purpose of this study is to present the clinical symptoms, radiological findings, and surgical indications of a giant frontal sinus osteoma with an orbital cavity expansion and secondary VI cranial nerve palsy. Moreover, histological findings of the tumor in the forms of granulomatous inflammation and tumor-infiltrating lymphocytes with single multinucleated giant cells brought our attention to provide additional antibacterial treatment and perform an osteoplastic operation 6 months later.