Synthesis of New Hydrazones Based on 1-(1-Tosylpyrrolidin-2-yl)propan-2-one

Yulia M. Sadykova, Аndrey V. Smolobochkin, Rakhymzhan Turmanov, Alena Vladimirovna Zalaltdinova, Almir Sabirovich Gazizov, Michail A. Pudovik, Alexander Romanovich Burilov

2024

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DOI 10.1134/s107036322407003x

Data confidence 70 medium

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Abstract

Abstract A method was developed for synthesizing previously unknown hydrazones containing two pharmacophoric fragments in their structure based on the reaction of phenyl/acylhydrazines with 1-(1-tosylpyrrolidin-2-yl)propan-2-one. Structure of the resulting hydrazones was established using 1H, 13C NMR, IR spectroscopy, and mass spectrometry (ESI-TOF) data. Based on 1D/2D correlation NMR experiments, it was found that the resulting hydrazones exist only as E-isomer.