Synthesis of cyclic sulfamides via one pot alkylation/aza-Michael cascade reaction

2024

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DOI 10.1016/j.tetlet.2024.155213
Data confidence 70 medium
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Abstract

A straightforward and transition metal-free method for the synthesis of cyclic sulfamides via base-promoted bis-alkylation of tert-butyl (N-alkylsulfamoyl)carbamates with electron-deficient allyl bromides is described. All obtained cyclic sulfamides underwent successful removal of tert-butoxycarbonyl protecting group.