Abstract
Polyethylene glycol fumarate (PEGF) with controlled structural composition has been obtained for further synthesis of double network crosslinked hydrogels for biomedical applications. The copolymer has been synthesized by polycondensation reaction of fumaric acid and polyethylene glycol (PEG-600). Molecular weight of PEGF has been determined by gel permeation chromatography to be approximately 6000 Da with gel permeation chromatography. The polycondensation of fumaric acid and PEG-600 was studied throughout the reaction process. The structure of the reaction product has been evidenced using FTIR- and 1H NMR-spectroscopy. The quantitative ratios of the amount of –C=C– bonds and –COO groups to –C=O groups in the obtained PEGF have been estimated from IR-spectra for different synthesis time. The time-dependence of molar ratio of double bonds to methyl groups in PEGF has been obtained from corresponding 1H NMR-spectra. FTIR and 1H NMR-spectroscopy, both, demonstrate that after the end of reaction the unsaturated –C=C– double bonds remain in the structure of the macromonomer, that is essential for further preparation of cross-linked hydrogels. The addition of the tightly cross-linked network of polyvinyl alcohol leads to formation of highly tough biocompatible material for preparation of the artificial meniscus which can further be used as a solution n the treatment of diseases such as osteoarthritis.