Poly(2-vinylpyridine) magnetite nanoparticles for 5-fluorouracil targeted delivery: synthesis, uptake and release study

Ilya V. Korolkov, Kairat A. Izbasar, Zh. A. Bekbol, Alexandr V. Zibert, Alena Euhenauna Shumskaya, Lana I. Lissovskaya, Luiza N. Korganbayeva, Maxim Vladimirovich Zdorovets

2024

Full text Open access: Green Metadata (CSL-JSON)

DOI 10.21203/rs.3.rs-3932808/v1

Data confidence 70 medium

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Abstract

Abstract One of the major limitations of anti-cancer drug is their poor selectivity and high toxicity. Present study is aimed overcoming these difficulties by development targeted drug delivery systems. Drug delivery systems were synthesized based on magnetite nanoparticles with grafted poly(2-vinylpyridine) from their pre-modified surface with 3-(trimethoxysilyl)propyl methacrylate. Physical and chemical properties of synthesized samples were examined by FTIR, XRD, VSM, EDA, Mössbauer spectroscopy. 5-FU release from nanocarriers was estimated using UV-Vis spectroscopy.