Abstract
links in the pathogenesis of various diseases are a potential therapeutic target of pathogenetic treatment. Modern trends and discoveries of metabolomics open a “window” for studying pathogenesis from the point of view of the interaction of inter-organ axes associated with the intestinal microbiota. Every second the intestinal microbiota through chemical reactions produces a huge number of substances, compounds, enzymes which called "metabolites". Currently, one of the widely studied metabolites is trimethylaminetrimethylamine-N-oxide (TMAO). TMAO is a substance formed by the oxidation of trimethylamine, a product of the breakdown of dietary free choline, phosphatidylcholine, and carnitine metabolism through the intestinal microbiota. The presented review examines the effect of TMAO on the mechanisms of occurrence and progression of diseases of the cardiovascular, gastrointestinal, endocrine, and nervous systems. Awareness of its role in the pathogenesis of chronic non-communicable diseases provides new opportunities in approaches to the treatment of patients.