Abstract
In order to ensure sustainable development and system management of livestock farming, the expansion of the scientific research boundaries and interdisciplinary focus of science is becoming increasingly important.In this regard, at the present stage in the field of animal breeding, especially in intensive livestock breeding, the possibility of early forecasting of long-term productive use of animals with high levels of productivity is becoming increasingly important, which in turn puts forward the need to combine the efforts of different branches of science.For example, in scientific research in the field of selection and breeding, more and more attention is paid not only to the appearance, but also to genotype of animals, in particular the isolation of individual species in the genotype, with a certain allelic state of genes.For the last years, the scientists of agrarian university have been actively studying somatotropin cascade genes, and it was decided to deepen studying the prevalence of alleles of this gene in particular breed, in particular Holstein breed of cattle, which is widely spread in Kazakhstan.The laboratory DNA-typing of Holstein breed on polymorphisms bGH-AluI, bIGF-1-SnaBI was carried out and the analysis of genetic structure of researched populations was carried out.The genotypes of each animal were established.The aim of this article is to evaluate the association of pair combinations of polymorphisms bGH-AluI, and bIGF-1-SnaBI with productive life expectancy of Holstein cows of Kazakh breeding was studied.In Holstein cows there is observed the strengthening of phenotypic effects towards an increase of milk productivity indicators in the pair combination¹ 1 bGH-AluILL-bIGF-1-SnaBIAA.In Holstein cows of record with diplotype bGH-AluILV-bIGF-1-SnaBIAA, strengthening of combined effect is observed in relation to separately taken genotypes by the trait of total milk yield.