DEVELOPMENT OF TECHNOLOGY FOR OBTAINING EXTRACT OF ZERAVSHAN THYME (THYMUS SERAVSCHANICUS KLOKOV) AND ITS STANDARDIZATION

Б.С. Жумаканова, Zuriyadda Sakipova, Liliya Ibragimova, А.А. Кесикова, M.B. Ibrayeva, S.V. Shvets, A.A. Bakytkhanova

2023

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DOI 10.53511/pharmkaz.2023.80.82.038
Data confidence 70 medium
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Abstract

S.D. Asfendiyarov KazNMU has developed an original technology for obtaining Zeravshan thyme extract. A method for obtaining the extract using ultrasound with a regulated frequency is substantiated, which makes it possible to get the maximum yield of biologically active substances from medicinal plant materials with established pharmaceutical and technological parameters. The technology of three pilot batches was transferred at the pharmaceutical company FitOleum LLP to GMP. Technological process validation was successful. Technological regulations for production, quality specification «Seravshan thyme liquid extract» and a draft regulatory document have been developed. Studies have begun on long-term stability testing of the product. The developed method for obtaining the extract is patented (patent No. 6830 dated February 4, 2022).