ISOLATION AND STANDARDIZATION OF GLYCYRRHIZIC ACID FROM LICORICE DRY EXTRACTS

2023

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DOI 10.53511/pharmkaz.2023.88.26.039
Data confidence 70 medium
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Abstract

This article provides research to optimization of obtaining glycyrrhizic acid from dry extracts of the licorice roots.Acid isolation was carried out from two types of extracts: 50% alcohol extract and aqueous extract.Glycyrrhizaglabra is a perennial plant, which can grow in various climatic conditions, including dry and hot regions of Kazakhstan. Stocks of licorice in Kazakhstan are quite extensive and are estimated at several thousand tons per year. Many scientific researches have been undertaken in conjunction with the COVID-19 pandemic, because of which it was discovered that licorice roots can help treat serious viral infections, including SARS-Cov-2. The purpose of this scientific research work is improvement way to get glycyrrhizic acid in its pure form, since, having large reserves of initial plant materials in Kazakhstan and using this technology, it is possible to increase the production of glycyrrhizic acid, the demand for which in the whole world is growing every year. Licorice roots (Glycyrrhiza glabra L.) collected in the Almaty region were used as plant raw materials. Standardization of pure compound was determined using high-performance liquid chromatography (HPLC) andIR-spectra on FT-IR spectrometer with a database that includes more than forty-six thousand spectra.