OBTAINING EXTRACTS FROM THE ROOTS OF FERULA PENNINERVOUS (FERULA PENNINERVIS REGEL & SCHMALH.) OR KELLER’S FERULA (FERULA KELLERI KOSO-POL)

A.M. Dzhumabaeva, Zuriyadda Sakipova, Liliya Ibragimova, Akmaral T. Kabdenova, D.B. Duisenbekova, M.B. Ibrayeva, B.O. Minbayev, A.E. Bolatbekova

2023

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DOI 10.53511/pharmkaz.2023.73.24.037
Data confidence 70 medium
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Abstract

At the pharmaceutical company Fitoleum LLP (Esik, Kazakhstan) a technology for obtaining thick and dry extracts of ferula penninervis or Keller’s ferula was developed, and the technological process of the pilot series was transferred and validated. As a result of the research, the regulating normative documentation for the proper production process under the established conditions was developed. Comparable data were obtained on the studied technological parameters of three successively produced batches of each product, and the validity of the considered technological processes for the production of extracts was confirmed. Introduction. The ferula plant (lat. Ferula) belongs to the umbrella family (Apiaceae). In folk medicine, it is widely used to treat dermatological, neuropsychiatric, ophthalmic and infectious diseases. Ferula penninervis (Ferula penninervis Regel & Schmalh.) and Keller’s ferula (Ferula Kelleri Koso-Pol) are of scientific and practical importance, having a wide distribution area in the southern region of the Republic of Kazakhstan, in areas with high solar insolation. Full-scale studies of representatives of the genus Ferula — ferula penninervis and Keller’s ferula, and the development of herbal pharmaceutical substances from their roots were carried out at S.D. Asfendiyarov Kazakh National Medical University. The aim of the study is to develop an optimal technology for obtaining an extract from the roots of the ferula penninervis (Ferula penninervis Regel & Schmalh.) or Keller’s ferula (Ferula Kelleri Koso-Pol) and its validation at the Fitoleum LLP enterprise in accordance with national requirements [1]. Materials and methods. Description of the production process. In the production of extracts, the following ingredients are used: dried roots of ferula penninervis or Keller’s ferula, collected in late autumn 2017 in the Kordai Pass, in accordance with the requirements of the relevant standard of cultivation and collection practice (GACP) [2]; purified water and ethanol 96% of pharmacopoeial quality . The technological process consists of the following classical operations: preparation of medicinal plant materials (MPM), preparation of the extractant, obtaining an extract from the MPM, purification of the extract, removal of the extractant, packaging and labeling (Figure 1).