SYNTHESIS AND ROOT FORMING ACTIVITY OF INCLUSION COMPLEXES OF HETEROCYCLIC THIOANHYDRIDES WITH ARABINOGALTAN

Sycheva Yelena Sergeyevna, Anuarbekova Indira Niayzbekkyzy, D.B. Markina, M. S. Mukanova, G.S. Mukanova

2023

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DOI 10.51580/2023-2.2710-1185.16
Data confidence 70 medium
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Abstract

Nitrogen-containing heterocycles are structural elements of many synthetic and endogenous biologically active substances. In this regard, they have particular interest as objects of study of the relationship between the structure and biological activity. The aim of this work is the development of new plant growth stimulants, based on nitrogen-containing heterocyclic dithiocarbamic acids and their inclusion complexes with arabinogalactan, and the study of their root-forming activity. Results and discussion. Synthesis of sodium dithiocarbamate of 5-amino-1,3,4-thiadiazole-2-thiol and its carbonyl derivatives cycloprapane, 4-fluoro- and 4-methoxybenzoic thioanhydrides has been carried out. Conditions for synthesis of the inclusion complexes of thioanhydrides 2-4 with arabinogalactan (AG) have been developed. The synthesis of the bioorganic inclusion complexes of substrates with AG has been carried out in the mass ratio of the initial reagents 1:1 in dimethyl sulfoxide, the duration of the reactions has been 8 hours at the temperature of 55-60 °C. The inclusion complexes with arabinogalactan have been obtained with the yield of 62-88%. The structure of the synthesized heterocyclic thioanhydrides has been established based on IR and 1H and 13C NMR spectroscopy. Field tests have been carried out to identify the root-forming activity of the obtained compounds and to determine the effect of the growth stimulants on the growth of the root system of vangutta spirea cuttings. Conclusion. It has been found that biocomplex 4-methoxybenzoic (5-mercapto-1,3,4-thiadiazol-2-yl)carbamothioic thioanhydride with arabinogalactan 7 increases the rooting and survival of the planting material and at the concentration of 100 mg/l shows a high yield of the rooted spirea cuttings (90%), as compared with the control (13% ) and standards Kornevin (20%) and AN-16 (36%).