DETERMINATION OF THE SPECIFIC ACTIVITY OF 177Lu AND ASSOCIATED RADIONUCLIDE IMPURITIES

2023

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DOI 10.37614/2949-1215.2023.14.2.011
Data confidence 70 medium
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Abstract

Radioactive isotopes of rare earth elements (REE) are increasingly used in nuclear medicine for diagnostic and therapeutic purposes as they have effective nuclear physical properties. Seventeen elements of the secondary subgroup of group III of the periodic table of chemical elements of D.I. Mendeleev with atomic numbers 21, 39, 57, 58-71: scandium, yttrium, lanthanum and 14 lanthanides make up rare earth elements. Every year more and more attention is paid to the radioactive isotope of lutetium 177Lu, the most promising for use in therapeutic agents of a new generation, including for cell therapy of oncological diseases. The advantages of 177Lu are determined by its nuclear characteristics: the optimal depth of penetration into human tissues during radiotherapy of small tumors and low radiation load on healthy organs are provided due to the maximum energy of beta radiation of 496 keV, the presence of low-energy gamma radiation of 113 keV allows monitoring the treatment process, the half-life of 6.71 days makes it possible to transport drugs from 177Lu to significant distances.