Post-vaccination Comparative Studies of the Dynamics of Antibodies Neutralizing the SARS-CoV-2 Virus During Vaccination with Various Vaccines in Kazakhstan

JM Bekshin, M Rysuly, AT Abishev, GK Akhmetova, А.С. Садвакас

2023

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DOI 10.31080/asgis.2023.06.0518

Data confidence 70 medium

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Abstract

Post-vaccination measurement of the level of antibodies neutralizing the SARS-CoV-2 virus (NA) in blood serum is a marker for monitoring the effectiveness of immunity formation [1,2].In 4 groups of 462 patients, a comparative study of the neutralizing effectiveness of antibodies was carried out with single and double administration of CoronaVac brand vaccines (SynoVac), VeroCell (Sinofarm), Sputnik-V (GamCovidVac) and domestically produced QazVac (QazCovid-in).Of the 462 vaccinated subjects examined for NA, 46 recovered from COVID-19 and 416 were not infected with the SARS CoV-2 virus.The latter were included in the present study.In 34 (8.2%) patients, threshold values of NA were not found in the blood serum after vaccination.The Chinese-made vaccines Vero-Cell and the Kazakhstani manufacturer QazCovid (Research Institute for Biological Safety of the Ministry of Education and Science of the Republic of Kazakhstan) had practically the same indicators of post-vaccination immunogenicity.