Abstract
Brucellosis is a particularly dangerous and socially significant infection, causing significant economic damage and causing a high level of disability of patients. Brucellosis is a systemic zoonotic infection transmitted from animals to humans through the consumption of infected products, direct contact with infected animals or inhalation with aerosols. It is caused by bacteria of the genus Brucella [ 1 ]. Fruits of P. drupacea Bge. exhaustively extracted with hexane by maceration. Next, the hexane extract was separated by silica gel column chromatography and a fraction was obtained, according to GC/MS, containing 96.69% of bakuchiol. The present experimental in vitro study was carried out to evaluate the anti-brucella activities of the bakuchiol-enriched fraction. The reference Brucella 16 M strain was studied using the serial dilution method. It was revealed that the studied Brucella 16 M strain was sensitive to this fraction even at low concentration (the ratio of solvent-extract is 1 : 0.039). The current findings have clearly demonstrated that the bakuchiol-enriched fraction of P. drupacea Bge. fruits extract possess antibrucellosis activity. Studies have shown the possibility of using the bakuchiol-enriched fraction of P. drupacea Bge. fruits extract as a bioadditive for the prevention and treatment of brucellosis in veterinary medicine. The authors declare no conflict of interest. Publication History Article published online: 12 December 2022 © 2022. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany