Abstract
Purpose of research. Effective R&D management is critical in the framework of transition to a knowledgebased economy, thus it is not only about the size of the R&D budget and the percentage of R&D expenditures, but also about the management of innovation activities in general. The article analyzes the evolution of management of knowledge-intensive industries and its features at each stage of development. Methodology. It was used a systematic analysis and structuring of scientific information; deduction method for determining the methodological foundations of foreign experience about system of management of knowledge-intensive industries. Originality / value of research. The study includes literature review on this issue which issue made it possible to highlight the main approaches to the management of knowledge-intensive industries in the context of Industry 4.0. It was given information about models of R&D management by generations and their features. Findings. The article presents the author's scheme of the system of management of knowledge-intensive industries and its components based on the open innovation approach, as well as the mechanisms of cooperation and communication "science-industry", which can be used in the formation of state programs for the development of science in the Republic of Kazakhstan.