Abstract
The article presents the results of the ultrastructural organization of animal hepatocytes under the conditions of peripheral tumor growth modeling. Hepatocarcinoma-29 was taken as a model of tumor growth, the cells of which were grafted into the thigh muscle tissue in CBA mice. The ultrastructure of hepatocytes was evaluated by light and electron microscopy under normal and distant tumor growth conditions after 3, 7, 13, and 30 days of the experiment. It has shown that by the 30th day of tumor development in the hepatocytes, structural signs develop, indicating a violation of the protein-synthetic and energy function of cells. There is a decrease in bulk density of the cisterns of the granular endoplasmic reticulum, mitochondria and the numerical density of attached and free polysomal ribosomes. The obtained results indicate the developing insufficiency of the secretory function of the liver under conditions of peripheral tumor growth.