The role of nuclear factor kappa B (NF-kB) in the pathogenesis of lung cancer

D.A. Akhmetova, Olga Bulgakova

2019

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.32523/2616-7034-2019-128-3-8-23

Data confidence 70 medium

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Abstract

Lung cancer is a leader in the mortality rate of malignant neoplasias around the world. The development and progression of a malignant tumor depends on the balance between cell survival and cell death signals. The main signal for cell survival is the nuclear factor kappa B (NF-kB), which plays a key role in carcinogenesis and resistance of cancer cells to chemo and radiotherapy. Recent studies have demonstrated a link between the activation of the NF-kB signaling pathway and the development of lung cancer. This review highlights the current understanding of the functional features of the NF-kB signaling pathway and its role in the pathogenesis of lung cancer.