POS-365 THE COMPARISON OF URINARY PROTEOME PROFILES BETWEEN CKD PATIENTS WITH PROTEINURIA AND HEALTHY INDIVIDUALS: PRELIMINARY DATA

Abduzhappar Gaipov, Zhanna Dauyey, Zhannur Markhametova, Zhalaliddin Makhammajanov, V. Kim, Assem Nogaibayeva, Larissa Kozina, Pavel Tarlykov, Rostislav Bukasov, Zhandos N. Utegulov

1 more author

Duman Turebekov

2022

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.1016/j.ekir.2022.01.387
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Proteinuria (PU) is a major marker of chronic kidney disease (CKD) severity and cardiovascular mortality. The mechanism of CKD progression in patients with proteinuria occurs via tubular toxicity by filtering proteins. Thus, more rapid CKD progression is expected in those patients who have higher levels of proteinuria. However, urinary proteomic profiles may differ among people, that is why there is a possibility of presence of “high-risk candidate” proteomes that might cause rapid progression of CKD.