Study of the kinetics of the release of lipophilic ingredients from capsules using synthetic and natural systems

Altynai Sharipova, Assem Issayeva, Saule B. Aidarova, Zhanar Ospanova, Akerke Bektursyn, Alpamys Babayev

2021

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.15328/cb1216
Data confidence 70 medium
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Abstract

In the work, the kinetics of the release of vitamin E and polyphyte oil from capsules was studied using synthetic and natural systems. The release of active ingredients was monitored on a Cary 50 Cons UV spectrophotometer equipped with CaryWinUV software. The kinetics of the release of vitamin E from capsules stabilized with sodium caseinate and then coated with chitosan shows a sustained prolonged release of 20% of vitamin E within 1 h, within 5 h about 45% is released, within 48 h about 80%. It was found that the efficiency of capsulation of vitamin E is higher than that of polyphyte oil, the release of vitamin E is more delayed and prolonged in comparison with polyphyte oil. The release of vitamin E from capsules stabilized with a synthetic system polymer-surfactant / vitamin E) chitosan) polystyrene sulfonate PSS was also investigated. It was determined that the release of vitamin E from capsules stabilized by a synthetic system (polymer-surfactant and coated with two layers of oppositely charged polyelectrolyte by the Layer-by-Layer method) is prolonged, within 1 h – 23% of vitamin E is released, 70% – within 12 h and 100% – within 80 h.