The influence of phytomedicine on metabolic processes of white rats undergone to ionized radiation

Oralbek Z. Ilderbayev, Erbolat Dalenov

2012

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DOI 10.1096/fasebj.26.1_supplement.859.18
Data confidence 70 medium
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Abstract

The purpose of this experimental research is to study the influence of gamma‐radiation on metabolic processes of white rats undergone to ionizing radiation. The is a conclusion of the ethical committee (protocol N5, 2010, State medical university, Semey). Animal experiments were carried out in accordance with the order of the Helsinki Declaration on the humane treatment of animals. The levels of LPO, diene conjugates (DC) and MDA in thymus, spleen and lymph nodes of small intestine were tested. In the II series of experiment 30 days after irradiation by common gamma‐rays in the dose equal to 6 Gray, the reliable increase of DC contents was observed, that was 2.75 times higher in liver, 1.37 times higher in lymph nodes of small intestine, 2.5 times higher in thymus and 2.38 times higher in spleen as compared to control animals. The MDA amounts significantly increased in thymus (in 1.68 times) and in spleen (in 1.7 times, ð<0.05). The increase of MDA concentration in liver was equal to 1.63 times (ð<0.05). No changes were observed in lymph nodes of small intestine. Finally, obtained research results show that in case of exposure to common gamma‐rays in a dose of 6 Gray, the concentrations of DC and MDA increase in liver, thymus and spleen.