The degree of expressed inconvertible damages of neurons and phagocytic activity of microglia of different parts of rats' cerebrum brain during prolonged inhalation by the vapour of flying narcotically affecting substances (FNAS)

2011

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DOI 10.1096/fasebj.25.1_supplement.lb333
Data confidence 70 medium
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Abstract

Morphometric research of quantity exponents occurrence of inconvertible damages of neurons (contracted neurons and cell‐shadows) was carried out: in the cortex of large hemispheres, in the thalamic areas, in the hippocampus and in the trunk of cerebrum, and also cells of Purkinye in the cortex of cerebellum, at daily inhalation by the glue vapour “Moment” and petrol vapour, during 30 days. Morphometric exponents of contracted neurons and cell‐shadows have demonstrated different expressed degree of cytotoxic reactions in the investigated perts of the cerebrum. It was established, that more sensitive to the cytotoxic effects of glue vapour “Moment” is the neurons of the cortex of large hemispheres and cells of Purkinye of cerebellum cortex, but to the cytotoxic effects of petrol vapour – neurons of thalamic areas of the cerebrum. It was revealed that toxic affection by the glue vapour is associated by large phagocytic activity of microglia in the area of thalamic zones, and affection by the petrol vapour – more expressed phagocytic activity of microglia cells in the cortex of large hemispheres, in the result of investigation of number of satellite cells on 1 neuron and neuronophagocytic nodules on 30 day of daily inhalations by the glue vapour “Moment” and petrol vapour.