Value of of Hemostasis in Ulcerative Colitis

Т Р Омаров, L.A. Omarova, Leonid Tell

2015

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DOI 10.1096/fasebj.29.1_supplement.849.1
Data confidence 70 medium
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Abstract

Relevance State of hemostasis in ulcerative colitis (UC) has not been studied enough. Goal of article Istostudy indicators of blood coagulation in patients with UC, depending on the degree of process activity. Materials and methods Standard hemostasis indicators have been studied in 27 patients depending on the degree of inflammatory process activity. Results and discussion Increasing the SFMC is most expressed at high and moderate activity UC and was 14,2 ± 0,33, 11,9 ± 0,28 mg / 100 ml, respectively, are 3.2 and 2.7 times compared with remission 4.45 ± 0,23 and healthy 4,03 ± 0,1. Shortening the time of ADP-induced platelet aggregation and 7,8 ± 0,33 9,36 ± 0,28 sec, respectively, depending on the activity level (10,7 ± 0,24 s remission and healthy 12,2 ± 0,4). The concentration of fibrinogen one of the acute phase proteins increased 1.6 times at a high degree of activity and 1.3 times at moderate and amounted to 5,4 ± 0,05 4,5 ± 0,2 and respectively (healthy 2,9 ± 0.14 g / l). Increase the INR on average in 1.3 times. Statistically significant increases the APTT only at a high degree of UC activity 32,0 ± 0,3. HP kallikrein lysis is extended at high and moderate activity 16.4 ± 0,46 and 14,2 ± 0,46 m (in remission 12,9 ± 0,28 min). Conclusions Changes revealed evidence of hypercoagulation and risk of thromboembolis developing, and also DICsyndrome. Hypercoagulability persists in remission and points to the persistence of a chronic process. (Published in Valeology j. №3 2014.)