Abstract
Relevance: Breast cancer is one of the most common malignancies with a high mortality rate all over the world, including Kazakhstan. Despite modern advanced diagnosis and treatment methods, breast cancer remains one of the top three «killer cancers.» Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce the breast cancer incidence. High treatment cost, antitumor drug resistance occurring during therapy, and significant side effects of chemotherapy urge the importance of prophylactic actions able to prevent the tumor disease. Purpose: To review the Vitamin D3 role and potential in breast cancer prevention. Results: The analysis of the literature reviews and original articles accessing the Vitamin D3 role in breast cancer pathogenesis and the study of the main antitumor mechanisms of Vitamin D3 action emphasize the need for large randomized prospective studies to determine the actual Vitamin D3 role in breast cancer pathogenesis and its possible inclusion in antitumor therapy regimens. Conclusion: The results obtained evidence the Vitamin D3 adjuvant potential in breast cancer treatment