ACUTE VIRAL HEPATITIS CAUSED BY SARS-COV-2

Gaukhar Kurmanova, E Bekzhanova, Gulzhan Trimova, Maulen S. Malgazhdarov, М Н Турбекова, Shafiq Ahmad Joya, Erkebulan N Bosatbekov

2020

Data confidence 70 medium

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Abstract

Background Liver damage during SARS-CoV-2 is more often manifested as part of a cytokine storm and is a predictor of a more severe course of the disease. However, there is scant information on spontaneous liver damage during coronavirus infection.Aims To report on the acute coronaviral hepatitis manifestations. Methods In our study, we analyzed two clinical cases with SARS-CoV-2 debuted with acute hepatitis.Results Patients who tested positive for coronavirus had symptoms of acute viral hepatitis, elevated transaminases titles and minimal lung involvement. Moreover, one of the patients developed diabetes for the first time. Steroid treatment resulted in improved liver function tests, clinical findings, but not diabetes.Conclusion These cases indicate that acute hepatitis can be an independent manifestation of SARS-CoV-2 and that liver damage can be combined with damage to the pancreas, causing diabetes. Timely therapy with an adequate dose of glucocorticosteroids helped to stop the progression of the disease and avoid complications.