Abstract
In the last 10 years, virtually all countries have faced a change in the structure of drug use due to a decrease in the number of opiate along with an increase in the number of users of the so-called “new” psy- choactive substances Upon data collection from 126 patients, a dynamic clinical study of 356 psychotic states due to the use of synthetic cannabinoids was undertaken. Consecutive stages of development of psychosis along with its delirious, oneiroic, and amentive-like clinical variants were identified. The likelihood of development of psychosis and its clinical variants is determined by a complex of clinical, biological, psychopathological, and socio-psychological factors. A complex of clinical, biological and socio-psychological factors was shown to determine the pathokinetic patterns of development of psychosis due to the use of synthetic cannabinoids. It was established that as the clinical picture of psychosis worsens, the psychopathological symptoms of a deeper level develop (hallucinations- delusions - mental automatisms - motor disorders) with a simultaneous gradual depletion of a psychopathologi- cal picture of psychosis due to a narrowing range of existing productive symptoms.