Abstract
With preeclampsia, the average levels of biochemical parameters in mild and severe form did not differ significantly from those in the group with uncomplicated preeclampsia of pregnancy. There is a tendency to a decrease in total protein and an increase in bilirubin, creatinine, urea, and blood trans- ferases as it becomes heavier. In the hemostatic system, there was also a tendency toward a decrease in fibrinogen and platelet count as gestosis worsened. The average hemostasis in the groups with pre- eclampsia did not differ from the group with uncomplicated pregnancy. However, thrombocytopenia was observed in 28% and 32% of cases with mild and severe forms of preeclampsia. Moreover, a pro- nounced decrease in platelet count (almost 10 times) was recorded in 5.4% of patients with severe pre- eclampsia. In patients with preeclampsia, the production of intracellular perforin in the regulatory cells- CD4+Perf+ lymphocytes was significantly reduced and increased - in natural killers CD16+Perf+ and CD56+Perf+.