Abstract
Synthesis, structure and computer bioprognosis new hydrazons based on hydrosides o-and p-hydroxybenzoic acidsInteraction of hydrazides of o-and p-hydroxybenzoic acids with substituted aromatic aldehydes yielded the corresponding hydrazone derivatives.Using the computer program PASS, a bioproject of N-arylidene hydrazones was carried out and it was shown that their expected activity combines both the physiological activity of the initial hydrazides of o-and p-hydroxybenzoic acids and the constituent components of the structural molecule.The structures of the synthesized compounds were studied by 1 H NMR and 13 C NMR spectroscopy, as well as with the data of the two-dimensional spectra COSY ( 1 H-1 H) and HMQC ( 1 H-13 C).The values of chemical shifts, multiplicity and integrated intensity of the 1 H and 13 C signals in one-dimensional NMR spectra are determined.Homogeneous and heteronuclear interactions are established using spectra in the formats COSY ( 1 H-1 H) and HMQC ( 1 H-13 C), confirming the structure of the compounds under study.X-ray diffraction study of N-(5-bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide, whose molecule is bound by a hydrogen bond to an ethanol solvate molecule.