Abstract
Cytogenetic analysis of populations of larvae of malarial mosquitoes of the East Kazakhstan region (Semey city, Urdzhar village) and in the foothills of Alatau. In the village of Urdzhar identified two species Anopheles: An. claviger and An. message; in the remaining studied areas - only An. messeae. In populations An. messeae established a high level of inverse polymorphism on the sex chromosome and the third autosome. Significant differences between alternative samples for the composition of inversions and the frequencies of their variants due to the ecological peculiarities of the regions were recorded. In the south of the species range (Almaty agglomeration) over the past decades, a significant change in the frequency of chromosome inversions associated with climate change has been revealed.