Abstract
Abstract— The dynamics of the structural and phase composition of Fe3O4 nanoparticles in different media is established. The dependence of the change in the degree of degradation on the acidity and the time of residence in a medium is established. X-ray diffraction and energy dispersive analyzes show there is a sharp increase in the concentration of defects in the crystal structure in acidic media, due to the presence of amorphous regions caused by the emergence of hydroxide compounds. It is established that using gold for the coating of Fe3O4 nanoparticles protects nanoparticles from degradation and amorphization. Knowledge of the rate and degree of degradation of nanoparticles allows clarification of the time frame for the applicability of nanoparticles with potential applications in biomedicine.