Abstract
The urgency of engineering of new effective myelostimulating drugs substantiated by the growingpercentage of incidence of various diseases hemodepression. One of the factors in the developmentof depressive diseases are negative environmental factors. Various kinds of radiation, heavy metals,petroleum products (solution Shtoddart), trinitrotoluol, pesticides, organochlorine compounds, lindane(gamma-hexachlorocyclohexane), DDT (dichlorodiphenyltrichloroethane), many drugs have a myelostimulating suppressive effect. Therefore, the search myelostimulating drugs relevant today. In addition,myelostimulating are widely used in ophthalmology and biotechnology. The newly synthesized azaheterocycles compounds with piperidinium core was investigated on myelostimulating activity on thecyclophosphamide myelodepressive model. Complex of 3-(3ethoxypropyl)-7-(2-morpholinoethyl)-3,7-diazabicyclo[3.3.1]nonan with β-cyclodextrin is compound BIV-68. Compound BIV-69 is presented3-(3-i-propoxypropyl)-7-[2-(1-piperazine)ethyl-)]-3,7-diazabicyclo[3.3.1]nonan as complex of withβ-cyclodextrin. 3,7-Diazabicyclo [3.3.1] nonane-9-one is fairly easily converted to oximes by treatmentwith hydroxyamine hydrochloride. Following benzoylation leads to benzoic ester, whose complex withβ-cyclodextrin is BIV-70. Complex of 1- (2-ethoxyethyl)-4-(oct-1-yn-1-yl) piperidin-4-yl propionate withβ-cyclodextrin is compound BIV-71. The compound of the BIV-69 had a high myelostimulating effecton the proliferation lymphomyeloid pools of blood on the cyclophosphamide myelodepressive model.By activity compounds BIV-71, BIV-68 and BIV-70 was inferior to the compound of the BIV-69. Thus,azaheterocycles compounds with piperidinium core are perspective for search of new effective myelostimulating drugs.Key words: N-alkoxyalkyl piperidines, diazabicyclononanes, benzoyloxime, 14-(oct-1-yn-1-yl)piperidin-4-yl propionate, myelostimulating activity