Abstract
Genital herpes is an important public health disease and is the leading cause of genital ulcer disease worldwide. After primary infection, the virus establishes a life-long latency in the sensory ganglia and recrudescences may occur at an unpredictable rate. Recurrent labial and genital herpes infections represent the majority of clinical manifestations of HSV infections. In the present study, ambulatory cards of 108 women with moderate and severe HSV infection were analyzed. Average age of study women was 32.8 ± 5.7 years. Study results analysis has shown that clinical symptoms manifestation varied depending on disease remoteness and herpetic infection severity. In overwhelming majority of patients (55.5%), frequency of herpetic infection relapses was 3 to 5 times (on average 5.6 ± 3.4 times) per year. Relapse duration varied 6 to 14 days and was 10.4 ± 4.2 days on average. In patients with moderate and severe HSV-infection, manifested decrease of cytokines level is observed: FNOα, IL-1β, INFγ, IL-4.