A new single-stage method for obtaining of betulin phenylcarbamates

2017

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DOI 10.1080/10286020.2017.1382480
Data confidence 70 medium
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Abstract

A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives - phenylcarbamates are valuable as bioactive substances.