Molecular Switch of AhR in Repression or Activation of Stem Cell Signaling

Yingqiu Xie, Xiuqing Zhang, Tomiris Atazhanova, Bin-dong Song, Qing Yang

2017

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DOI 10.2174/1574362412666170207103318
Data confidence 70 medium
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Abstract

Background: Aryl hydrocarbon receptor (AhR) is an exogenous ligand-activating or constitutively active transcription factor. AhR regulates cellular differentiation, cell migration and other molecular and cellular processes. In general, AhR is biologically a very complex molecule in terms of its structure and functions in stemness, differentiation and clinical diseases. Here we review the debated issue of AhR in stem cell and cancer stem cell signaling. Keywords: AhR, cancer, stem cell, OCT4, TCDD, molecular switch.