Abstract
Basic elements of the national security include the development of own pharmaceutical industry. New drugs are currently created in Kazakhstan on the basis of local medicinal plants. One of them is tincture "Limonidin", obtained by the leading author from the roots of Limonium gmelinii , for which the technological scheme of production was developed at pharmaceutical company "Chempharm". Safety and efficacy of tincture has been shown during its clinical trials at two leading hospitals in Almaty: complete relief of symptoms, improvement of the endoscopic picture in patients with chronic diseases of the gastrointestinal tract: esophagitis, gastritis, and duodenitis, as well as in patients with non-infectious nature of the disease, especially in patients receiving long-term non-specific anti-inflammatory drugs or glucocorticosteroids. Tincture "Limonidin" was also tested on patients with antibiotic-associated diarrhea, caused by the combined seven-day administration of two antibiotics – amoxicillin and clarithromycin during eradication therapy for Helicobacter pylori -associated gastric diseases and 12 duodenal ulcer; in an outpatient setting at scientific and clinical diagnostic center (at the Institute of Cardiology and Internal Diseases under the Ministry of Health Care of the Republic of Kazakhstan). Positive clinical and bacteriological dynamics in the absence of side effects allows recommending the tincture "Limonidin" for the treatment of diarrhea. Strong anti-inflammatory effect in the treatment of inflammatory diseases within postoperative period with absence of allergic reactions or other side effects has been shown during the clinical trials both on patients with acute odontogenic purulent inflammations of the maxillofacial area, and patients operated for sinusitis and jaw cysts. On the basis of conducted clinical trials tincture "Limonidin" was recommended for introduction into medicine and for the industrial production as an anti-inflammatory drug in 2011.