Status of Lipid Peroxidation and the Immune System in the Remote Period after a Sublethal Dose Of Gamma Radiation

2015

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DOI 10.1096/fasebj.29.1_supplement.568.3
Data confidence 70 medium
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Abstract

We studied the intensity of free radical processes in organs (liver, spleen, thymus, lymph nodes of the small intestine, and adrenal glands) and cells (lymphocytes) and immunity system in the remote period to a sublethal dose of γ‐radiation (6 Gy). To investigate the immunity system and the lipid peroxidation of laboratory animals (white rats) in two series of experiments. All rats were divided into 2 groups: I – controls, II group – animals exposed to radiation. As opposed to the said tissues in hepar, there were material changes. MD sustentation was at the level of intact animals exponent (there is the tendency to rise). Given fact show that there are big compensation abilities of hepatic tissues which enables abnormalities arresting of free‐radical processes induced by the effect of ionized irradiation In such a manner, at the irradiated rats in the remote period were revealed decrease in the main indicators of immunity, the quantity of T‐lymphocytes, a supressiya of nonspecific phagocytic protection of an organism defense. There was CYC increase in blood serum. Perhaps, it was the result of uprising of organism autoimmune response on conjugated antigen. After the radiation effect, in remote period, there were abnormalities in the peroxidation process of lipids in mainly under investigation immunocompetent organs and tissues.