Abstract
Background . The research results of fat-soluble vitamin D 3 (cholecalciferol) encapsulation with β -cyclodextrin have been presented in this work. The vitamin D 3 inclusion complex with β -cyclodextrin was obtained under microwave radiation. The surface morphology of obtained clathrate inclusion complexes was described with the help of a scanning electron microscope. The thermographic measurement results on a differential scanning calorimeter have been presented. The activation energy of the β -cyclodextrin : vitamin D 3 clathrate complex thermal oxidative destruction reaction was calculated. The clathrate thermal destruction kinetic parameters were determined. The inclusion complex spectral properties were characterized by IR-Fourier and 1 H and 13 C NMR spectroscopy. The existence of β -cyclodextrin inclusion complex with vitamin D 3 in a 2 : 1 ratio was confirmed by the experimental results. The activation energy of thermal destruction of the inclusion complex of β -cyclodextrin with vitamin D 3 was calculated using four different methods.