Abstract
The genus Limonium comprises 300 species and most of them can be found in Kazakhistan. Reports of the phytochemical investigation of Limonium species from Kazakhistan had resulted in isolation of different classes of bioactive compounds mostly phenolics. Bioactive guided fractionation of Limonium myrianthum resulted in the isolation of 5,7,3',4',6'-pentahydroxyflavon-3-ol ( 1 ). The compound displayed significant antifungal activity against Candida glabrata and Candida krusei at IC 50 4.44 and 9.56µg/mL respectively. Biotransformation of 1 was done by Absidia glauca for further bioactivity and resulted in the formation of two new sulfated derivatives named as 5,7,3',6'-pentahydroxyflavonol-4'-sulfate ( 2 ) and 5,7,3',6'-tetrahydroxyflavonol-8,4'-disulfate ( 3 ). Acknowledgments : We are grateful to Dr. Bharathi Avula, for assistance with the HR-ES-IMS, and Dr. Melissa Jacob for conducting the antimicrobial testing . Z.A.K. and A.G. are grateful to the Khazakhstan government for financial support.