Abstract
The problem of effective and rational treatment of no viral hepatitis is still actual. During several last years, the screening of the bioactivity of the list of semi-synthetic derivatives of alkaloid cytisine was held in our laboratories. The result was the synthesis of O,O dimethyl-N-cytinizylphosphate (cytisin amidophosphate). Hepatoprotective properties were noted on the several models of acute and chronic hepatitis. Purpose: to study the efficacy and safety of cytisin amidophosphate under the name of Cytaphat in patients with toxic hepatopathy.