Abstract
to increase effectiveness of systemic radiation therapy of non-Hodgkin's lymphomas on the biorhythm base. 60 patients with NHL were randomized into two groups between 1998–2000. All patients underwent systemic radiation therapy (subtotal body irradiation) as an alternative to polychemotherapy. The subtotal body irradiation was performed by two opposite fields 40×40 cm by 18 MV of Linac. Dose per fraction were 2.0 and 3.0 Gy delivering 3 times a week, 3 fractions, with total dose – 6.0–9.0 Gy. Before radiation therapy electric conduct and temperature were measured in 12 acupuncture points every two hours in group 1 (30 patients). Then the degree of “general” and “pathological” misbalance in diurnal (daily) biorhythms were determined. On the base of these data systemic radiation therapy was performed. Group 2 was control. In group 1 complete and partial (more than 50%) response was observed in 28 patients (93.3%) vs. 24 patients (80.0%) in control. Toxic effects were considerably low in group 1. All patients of this group had no III-IV grade general toxic effects. They were observed in 40.0% patients in control. The period of misbalance maximum in acupuncture points is the most preferable to carry out radiation therapy. Biorhythm based radiation therapy is likely to be an effective treatment of NHL that considerably increases local control with the low toxicity rate.