Untitled

Ubaidilla Datkhayev, Aidar K. Berkenov

2017

Closed access Metadata (CSL-JSON)
DOI 10.22377/ijgp.v11i02.1041
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Aim: Search the main sources of biologically active substances from raw materials of plant genus Echinops L. standardization of extracts from raw materials of plant genus Echinops L. Materials and Methods: Ultraviolet spectroscopy, one-dimensional paper chromatography, atomic adsorption spectroscopy, gas-liquid chromatography method, concentration and sublimation method, mass spectroscopy, and nuclear magnetic resonance. Results and Discussion: Two major alkaloids were isolated from the ethanol extract of Echinops albicaulis. The isolated compounds were chemically identified as echinopsin (1)1-methyl-4(1H)-quinolone; 1,4-dihydro-1-methyl-4-oxoquinoline; N-methyl-4quinolone (C10H9NO), echinorin (2)1-methyl-4-methoxyquinolinium (C11H12NO). Compounds FR-100-2 showed antileishmanial activity against Leishmania donovani and Trypanosoma brucei with IC90 values of 5.33 μg/ml and 1.8 μg/ml, respectively. A technological scheme for the preparation of a drug substance from plants Echinops L. Conclusion: The study indicates that in endemic plants contain a large amount of alkaloids; this is necessary for the standardization of plants. What are the excipients which can be used for making pill of apple cider vinegar a useful active ingredient as a diet supplement and antiobesity formulation.